Preheat your oven to 400°F. Line a large baking sheet with parchment paper.
Arrange the pepperoni slices in a single layer on the baking sheet, making sure none of them overlap. Sprinkle lightly with the Italian seasoning and garlic powder.
Bake for 8 to 10 minutes, until the pepperoni slices are deeply colored, slightly curled at the edges, and beginning to crisp. They will still feel a bit soft when hot.
Using tongs, transfer the pepperoni chips to a plate lined with paper towels to absorb excess grease. Let them sit for 3 to 5 minutes. They will become beautifully crunchy as they cool.
Serve the crispy pepperoni chips with ranch dressing on the side for dipping. These are incredibly addictive and take barely any effort.
